Endotoxin is a potent toxin contained in cell wall components of Gram-negative bacteria. Since it brings about the fever or lethal shock when entering the blood of a person, it is necessary to confirm that medicines are not contaminated with endotoxin. Wako pioneers endotoxin measurement and has evolve the endotoxin measurement technology by manufacturing lysate reagents and developing the measurement system “Toxinometer”, and supported medicines for over 30 years.